SFAT scientific seminar
The thematic research pole “Fundamental and Applied Sciences, Technology” is organising its first scientific seminar.
Topic: Engineering for Health
When: 9 February 2021
Where: La Commanderie – 2 Rue d’Azans, 39100 Dole
Program
08:30 – 09:00 AM: Welcome
09:00 – 09:15 AM: Foreword
09:15 – 09:55 AM:
Mathematical modelling, combined with numerical and analytical investigations of these models have been used over the years to address various problems related to cancer. Here I will review some of these mathematical approaches that have been applied to predict the spatial spread of brain tumors, test oncolytic virus therapy protocols, or make predictions about the role of heterogeneity of immune cells in the evolution of cancer
Raluca Eftimie / LMB UMR 6623
raluca.eftimie@univ-fcomte.fr
Application to the context of functional rehabilitation: while there is a growing interest in the personalisation of medicine, virtual reality applications in health care still generally propose identical immersion modalities for all subjects whose sense of presence in the virtual environment is evaluated via questionnaires. The objective of our current work is to personalise the immersion modalities and to evaluate in real time the sense of presence by physiological measurements and thus improve the existing therapeutic solutions, in particular in the framework of functional rehabilitation.
Christophe Guillet / LISPEN EA 7515
christophe.guillet@u-bourgogne.fr
09:55 – 10:30 AM: Break
10:30 – 11:10 AM:
Video health monitoring has recently emerged as a promising alternative for the monitoring of several health indicators such as cardiac and respiratory rhythms. Due to its non-contact nature, this technology significantly improves patient comfort and paves the way to many new applications. We will present the different algorithms allowing the estimation of the photoplethysmographic signal by video analysis and will also present different examples of applications.
Yannick Benezeth / ImViA EA 7535
yannick.benezeth@u-bourgogne.fr
In recent years, the international neuroscience community has turned to novel control-system methods (system identification, also called reverse-correlation) in an attempt to characterize how the human brain processes information in external stimuli such as speech. Contrary to traditional neuroimaging methods which infer statistical properties at the level of a group of individuals, these new engineering methods allow studying brain function at the individual level, and hence offer promises for patient diagnosis and prognosis. In this talk, we will present two recent research projects, which explore the use of reverse-correlation in the context of the diagnosis of voice perception disorders in brain stroke survivors and the prognosis of recovering awareness in coma patients.
Jean-Julien Aucouturier / FEMTO-ST UMR 6174
jean.aucouturier@femto-st.fr
11:10 AM – 01:30 PM : Lunch break & posters session
01:30 – 02:10 PM :
Workers exposure to hand-arm vibrations leads to vascular pathologies such as Raynaud’s syndrome. Repeated and prolonged reduction in blood flow causes proliferation and migration of excessive smooth muscle cells leading to the phenomenon of intimal arterial hyperplasia. The cellular mechanisms are represented by an agent-based model coupled with finite element method to predict the growth kinetics that reduces the artery lumen.
Emmanuelle Jacquet / FEMTO-ST UMR 6174
emmanuelle.jacquet@femto-st.fr
The Nano-Neuro-Med project aims to help elucidate the mechanisms involved in neurodegenerative diseases.
This project will illustrate the different approaches used in the service of health: synthesis of original hybrid nanoparticles as therapeutic and diagnostic nanovectors, innovative multi-frequency AFM techniques for the analysis of biological samples, spectroscopy techniques on single molecule and theoretical physics and high performance numerical computation for the modeling of biological macromolecules.
Patrick Sennet / ICB UMR 6303
patrick.senet@u-bourgogne.fr
02h10 – 02h30 PM: Break
02h30 – 02h30 PM:
Multifunctional gold nanoparticles have been developed that show promising potential for image-guided therapy. In order to ensure better therapeutic use of these nanoparticles, strategies are proposed which aim both at postponing renal clearance and at improving targeting.
Stéphane Roux / UTINAM UMR 6213
stephane.roux@univ-fcomte.fr
Long limited to in vitro studies, optical fluorescence imaging is increasingly becoming a modality of choice for in vivo studies. The Wazaby (Water-soluble aza-BODIPY) fluorescent platform was developed to meet this growing need. It allows the rapid design of near-infrared emitting contrast agents for surgical assistance, bimodal imaging agents and theranostics.
Ewen Bodio / ICMUB UMR 6302
ewen.bodio@u-bourgogne.fr
Radiotherapy (RT) is one of the central treatments in the management of cancer patients. It is now established that RT has both a direct impact on the survival of cancer cells, via the induction of DNA damages, but also an impact on the immune response. Depending on the administration methods, RT can induce an anti-tumor immune response, by recruiting lymphocytes into the tumor, or pro-tumor response by inducing immunosuppressive mechanisms. These justify the development of combinations of RT and immunotherapies which are currently booming in the clinic.
Céline Mirjolet / CGFL – INSERM 1231
cmirjolet@cgfl.fr
03h30 – 03h50 PM: Break
03h50 – 04h30 PM: Round table – Contribution of Computer Science and Artificial Intelligence in Health
04h30 – 05h00 PM: Poster awards