ISITE-BFC promotes excellence and internationalization of research in Bourgogne-Franche-Comté. ISITE-BFC relies on a rigorous selection procedure and on the competence of international experts for the evaluation of candidates and their projects.
Fellowships are awarded to excellent or rising researchers from UBFC, and to junior Tenure Tracks and high level international researchers, to work on ambitious and high quality research projects.
ISITE-BFC aims at boosting the research in the Bourgogne-Franche-Comté Region through Tenure Tracks job offers. These fellowships are granted to promote young researchers who show the potential to reach European Research Council (ERC) or Institut Universitaire de France (IUF) recognition within the period of the fellowship. They play a leading and positive role for research laboratories and host structures.
James Schmidt has expertise in research on learning, attention, cognitive control, and neural networks. His primary experimental research line focuses on human contingency learning. That is, he studies how we learn (often unconsciously) the regularities in our environment and use this knowledge to better interact with our world. He also does a lot of research on attention and cognitive control, albeit primarily as a critic of mainstream cognitive control theories. This includes work on conflict monitoring and attentional control, in addition to recent work on task switching. He has considerable expertise in neural network modelling. In particular, he programmed a neural network model of episodic memory that he has been applying widely to a broad range of research fields. He has also published work on temporal learning, formal reasoning, binding, and the Stroop effect.
Keywords: cognitive psychology, neural networks, contingency learning, binding, attention, cognitive control, timing, task switching, computational modelling, episodic memory.
Simon KIMBER is a materials chemist, with significant expertise in electronic and magnetic properties. He has worked in central facilities for synchrotron and neutron scattering, and made significant R&D advances in scattering techniques. He has applied these to both solid state and solution phase systems, and has recently developed an interest in the interfaces between solvated species and solvent.
Keywords: X-ray and neutron scattering, in-situ measurements, materials chemistry, nanoparticle interfaces, solvent restructuring.
Lab Host: Institut Mathématique de Bourgogne – IMB
Taro KIMURA’s scientific expertise is based on theoretical physics, in particular, mathematical aspects of quantum field theory. He has been working on supersymmetric gauge theory and superstring theory with emphasis on its connection to quantum algebraic structure, e.g., W-algebras, quantum affine algebras, arising through deformation quantization of the associated moduli space. He also has been exploring the geometric correspondence between the gauge theory moduli space and the classical/quantum integrable system. The main tools used in his studies are based on the geometric and algebraic approach to matrix model, quantum inverse scattering method in quantum integrable systems and the path integral localization for supersymmetric gauge theory.
Keywords: Quantum Field Theory, Superstring Theory, Supersymmetric Gauge Theory, Conformal Field Theory, W-algebra, Quantization of Moduli Space, Integrable System, Random Matrix Theory
Lab Host: Lipides, Nutrition, Cancer – LNC
Olivier BURGY has acquired significant expertise in pulmonary fibrosis. He has studied the mechanisms leading to the development and progression of pulmonary fibrosis and the heat shock proteins (HSP) involvement in these processes, as well as their role as potential therapeutic targets. His work has shown that inhibition of HSPB5 (HSP that promotes cell migration and invasion by modulating signal transduction pathways in cancer pathologies) inhibits fibrosis induced by the anti-cancer agent bleomycin. Olivier BURGY has also developed a research axis on the role of extracellular vesicles (EVs) in experimental and human pulmonary fibrosis. Through his scientific career, he has acquired a solid knowledge of cellular and molecular biology, particularly in development signalling (TGF, WNT) and in wound healing/tissue fibrosis processes.
Keywords: Extracellular vesicles, heat shock proteins, idiopathic pulmonary fibrosis, fibrosis, bleomycin, biomarkers, theranostic, developmental signaling pathways, translational science.
Lab Host: Agroécologie
With her background in ecology and political science, Juliette YOUNG has developed a unique interdisciplinary expertise in political ecology (consideration of human dimensions in the conservation of Nature). Her research, carried out in different settings (agriculture, forestry, fishing, hunting) and contexts (Europe, Asia, Africa), covers the policy cycle from its inception to its implementation. It integrates science-policy dialogue, knowledge co-production, associated conservation conflicts and their resolution, and evaluation of social and biodiversity outcomes. Juliette YOUNG is involved in new interdisciplinary research in which she adapts her portfolio of social science skills and methodologies to better understand socio-ecological systems, advancing knowledge to ensure a more sustainable future.
Keywords: Political ecology, conflict management, farming, land-use systems, forestry, hunting, fisheries, Europe, Asia, Africa, mixed-methods approaches, public participation, sustainability, inter-disciplinarity
France / Royaume-Uni
Her research work contributes to the numerical analysis and the development of efficient numerical methods having a guaranteed precision for problems (in particular partial differential equations) arising from electronic structure calculation, quantum chemistry and materials science. Geneviève DUSSON has an expertise in numerical analysis, in particular in a posteriori error analysis and adaptive meshes for finite element methods. She performed error estimations for linear and nonlinear eigenvalue problems with different discretization methods (spectral, conforming and nonconforming finite elements). She also works on data-driven modeling, and machine learning techniques for interatomic potentials in materials science.
Keywords: Numerical analysis, PDEs, a posteriori error analysis, linear and nonlinear eigenvalue problems, Schrödinger equation, perturbation method, data-driven modeling, high-dimensional approximation
Fabrice DAMON area of expertise is the cognitive development of human and nonhuman primates with a special focus on social cognition through the perspective of face processing. Familiar with the theoretical and technical aspects of facial processing, he is also proficient in designing infant research paradigms (e.g. habituation, visual paired comparison, etc.) using behavioral and imaging measures (e.g. eye-tracking, EEG, etc.). Fabrice DAMON is particularly interested in gaze behavior, which can inform on multisensory integration, for instance in the audiovisual (e.g. detection of synchronous audiovisual flow) or in the visuo-olfactory domain (e.g. face scanning in context of odor, odor/facial emotion matching). His work has led to the identification of a common mechanism of face perception in human and macaque infants, the finding of a strong visual for adult faces in infants during the first 6 months of life and the finding of a species-specific effect of face attractiveness in adult humans and macaques, highlighting the interaction of mate-choice adaptation mechanisms (species-specific) and general sensory biases (shared between primates).
Keywords: Infant cognitive development; Social cognition; Face processing; Multisensory integration (vision-olfaction); Categorization; Eye-tracking; Electroencephalography; Comparative studies.
Lab Host: Agroécologie
Samuel JACQUIOD has gathered a solid expertise as a general soil ecologist, including other trophic levels such as fungi, nematodes, protists, earthworms, and plants. Willing to develop practical applications of his research in microbial ecology, he has notably worked on the valorization of waste/recalcitrant bioressources, the discovery of novel functional genes of industrial interest, the improvement of plant growth, and environmental pollution diagnosis using molecular bioindicators. Samuel JACQUIOD also trained in bioinformatics and biostatistics, fields in which he is now recognized as an expert. For several years now, he has been interested in experimental evolution in order to better understand the links between microbes and plants and their consequences on plant growth, as well as the role of microbes in above- and belowground interactions, especially between plants and earthworms.
Keywords: Microbiology, ecology, agroecology, plant physiology, molecular biology, evolution, (meta)genomic, (meta)transcriptomic, bioinformatic, biostatistic, biotechnology, environmental sciences.
International coach fellowships
One of the ISITE-BFC objectives is to make possible for UBFC Research to benefit from the operational advices of internationally renowned researchers (coaches). A portfolio is granted to a foreign researcher enjoying a very high reputation in his field of research in order to coach projects to be implemented within an existing team of UBFC.
Host Lab : Biogéosciences
Pieter VISSCHER will work as a joint professor. He is currently full Professor and researcher among the leaders in the field of geomicrobiology. He also is -among many other responsibilities- project leader in major National Science Foundation programs and founder and chief administrator of UConn’s Center for Integrative Geosciences. He collaborates with the industry (Petrobras, Unisense) and was intimately involved in the founding of NASA’s Astrobiology Institute.
With (post)graduate degrees and extensive training in Atmospheric Chemistry, Geochemistry, Marine Sciences, Microbiology, Biogeochemistry and in Environmental Law, his specialty is in Geomicrobiology, with a focus on biosignatures in modern and recent sedimentary systems and with applications in Astrobiology. Specifically, he focuses on the role of microbial metabolism and microbial expolymers in precipitation and dissolution of minerals (e.g., carbonates, silicates). He also investigates the production and consumption of biogenic gases (e.g., volatile sulfur, methane). More recently, he has studied fabrics of microbial deposits and biotic and abiotic alterations of these during early diagenesis
Keywords : Geomicrobiology, ecophysiology of sulfur bacteria, exopolymeric substances, microbe-mineral interactions, microbial mats, quorum sensing, biogenic gases, Astrobiology.
Holder of the Epstein/Atkinson Chair in behavioral economics, Uri Gneezy is a professor of Economics and Strategy at the University of California in San Diego / Rady School of Management. He is considered as one of the world’s top experts in his field. Uri Gneezy is known for designing simple, clever experiments to demonstrate behavioral phenomena that open up new research axis in behavioral economics. Examples include his work on when and how incentives work, discrimination, deception, gender differences in competitiveness and behavioral pricing. His research is driven by new and original questions that the literature has not yet studied.
UBFC Junior fellowships
ISITE-BFC aims to facilitate the realization of talented UBFC researchers’ projects by providing appropriate work conditions, teaching charge reductions, administrative & technical support.
UBFC Junior Fellowships are granted to promote young BFC researchers who have the potential to be awarded an ERC grant.
π-extension of aromatic compounds by intramolecular oxidative coupling with a peripheral conjugated substituent (=fusion reaction) is currently an active research field in molecular chemistry since numerous potential applications are expected (PDT,IR absorption, solar cells, molecular conducting materials…). This project aims at 1) synthesizing porphyrinic precursors to be fused, 2) synthesizing and exploring the reactivity of fused compounds, 3) transferring the reactivity observed in solution onto a surface by grafting the unfused precursors/fused compounds leading to switchable materials.
BREATHING LIGHT(BRIGHT) project aims to explore a new class of nonlinear waves, called “breathers” and related to the well-known Benjamin-Feir instability phenomenon. In contrast to basic solutions of the nonlinear Schrödinger equation, breathers exhibit richer dynamics that makes them unique objects, with a large range of applicability that could be developed. In this project, the remarkable potential of nonlinear fiber-based platforms in ultrafast optics is expected to become the ultimate test-bed of breathers both for fundamental and applied aspects. Benefiting from their specific dynamical features, the disruptive innovation is to open the way to breather-based functionalities in optical signal processing architectures. To go beyond the frontier in terms of testing, manipulation of breathers is planned to be investigated in complex optical systems, including multi-variable, inhomogeneous and dissipative propagation. Moreover a multidisciplinary and complementary approach is provided through breather analysis in hydrodynamics and electrical transmission lines.
Th17 cells frequently infiltrate tumour and impact of tumour growth. While tolerogenic Th17 cell are associated with tumour progression, inflammatory Th17 are associated with antitumour immune response and tumour regression. We recently made the observation that NLRP3 is not only an adaptor involved in NLRP3 inflammasome assemblage but could also act as a transcriptional factor that controls Th2 polarization. In our preliminary data, we observed that NLRP3 also impedes the differentiation of Th17 and could switch differentiation between tolerogenic and inflammatory Th17 cells. This program has the objective to explain the molecular mechanisms by which NLRP3 is involved in Th17 differentiation in vitro to unravel the molecular mechanism of action of NLRP3 in Th17 cells. We have generated the first NLRP3 flox mice and we will use these mice to test the effect of NLRP3 deficiency only in T cells in the setting of growing tumour. Using this model, we will unravel if NLRP3 deficiency in T cells affects Th17 generation, the related antitumour immune response and tumour growth. Thus, this study will be the first study to decipher the role of NLRP3 protein in mice Th17 cells and will make the proof of concept that NLRP3 could be a target to boost antitumour immune response.
The concept of this project is to demonstrate new strategy for wave control for functional devices and new metamaterials. First, the cloaking mechanism, initiated by the transformational optics, has been theoretically extended via richer constitutive models. Second, the required mechanical metamaterials for transformational elasticity, such as Cosserat or Willis metamaterials have been studied. We have further fossed on general mechanical metamaterials and have even pursue in the field of topological transport.
Training by gesture repetition is an undeniable practice for new motor skills acquisition and consolidation, such as playing the piano, driving a car, or doing a gymnastic routine. However, it is not the only way to learn. A well-known alternative method is mental training. This practice can be used by the sportsman, the musician or the surgeon, to improve his operative gesture; it can also be used by the patient to facilitate his rehabilitation. The aim of this project is to determine the nervous components involved in mental training and to explain how the system adapts following mental training. By using complementary stimulation and recording techniques, it is possible to question the different stages of our system involvement, from the brain to the muscles and the spinal cord.
|Ce projet est co-financé par la Région BFC|
Lab : Biogéosciences
The IMVULA («rainfall» in Zulu) project aims at characterizing Southern African climate variability, assessing its predictability at different timescales, as well as its impact on carbon fluxes in the soil –a matter of increasing importance under climate change.
The core of EATERS is to investigate the brain mechanisms of Odor-Induced Taste Enhancement (OITE) in obese and normal weight population. Odors have the natural property to induce a taste. Yet odors and taste are perceived through independent senses, which never interact but in the brain. OITE processes are mostly unconscious, but decisive for food choices. With latest advances in brain imagery, they became accessible (electroenchephalography -EEG; and functional magnetic resonance – fMRI). The use of these odors in food is a relevant strategy to develop innovative food products with reduced amount of salt and sugar, while keeping the pleasantness of food. In this multidisciplinary project lies on the use several approaches to explore different facets of OITE mechanisms, mechanisms will be explored in obese persons, as they are directly concerned by the health impact of this salt/sugar reduction strategy. The main objectives of EATERS are twofold, a fundamental and an applied objective: (1) to gain insights in the mental representation of food on obese and normal weight populations, which is a decisive criterion during food behaviors, and (2) to study if this strategy is effective and robust in obese and normal weight population.
- CHU Dijon
SoluTiOn 2.0 project aims to produce low loss titanium dioxide waveguides in order to demonstrate an integrated broadband wavelength converter from usual telecommunications bands to the new waveband at 2 μm.
SmarTZ is a chemistry and reactivity project based on the molecular metal catalysis for the development of next generation of tetrazine materials and pharmaceuticals.
UBFC senior fellowships
ISITE-BFC aims to facilitate the realization of talented UBFC researchers’ projects by providing appropriate work conditions, teaching charge reductions, administrative & technical support.
UBFC Senior Fellowship encourage the development of ambitious or high-risk research projects by brilliant senior researchers of BFC. They can lead to a Senior ERC or IUF grant, or to develop an ambitious project contributing outstandingly to the international reputation of UBFC.
Laboratoire : Laboratoire Interdisciplinaire Carnot de Bourgogne – ICB
This project aims to develop an optical spectroscopy method able to perform a noninvasive and realtime detection of volatile organic compounds in the exhaled air of which excessive concentration can indicate serious diseases such as diabetes, Parkinson disease, peptic ulcers, and certain types of cancer.
Lab : LNC
Because cancer cells re-wire their metabolism, they need for their survival a high content of stress-inducible chaperones like heat shock proteins (HSPs). This cancer cells’ addiction to HSPs is the basis for the use of HSP inhibitors in cancer therapy. Several recent clinical studies have shown that one of them (still quite unknown) called «HSP110» is particularly relevant in colorectal cancer.
This ISITE project aims at deciphering the role of this HSP in colorectal cancer and to perform studies from structure to drug design in order to propose specific inhibitors that could be used in patients. Toward a more personalized medicine, they propose to demonstrate that HSP110 levels in blood samples correlated with HSP110 expression in tumor biopsies. Therefore, measuring circulating HSP110 levels will help to select the population that may benefit the most from the proposed HSP110-targeted therapy.
- CHU Dijon
- Humanitas Clinical and Research Center (Italie)
- MIT (Boston)
- ESRF (Grenoble)
- Affilogic (Nantes)
The tremendous importance of microbial communities for ecosystem functions is becoming increasingly evident. Microbes are not only driving all major biogeochemical cycles but also are directly and indirectly supporting a range of ecosystem services Yet the ability to accurately predict and manipulate these complex microbial communities in most environments is extremely limited if not non-existent.
In this context, the objectives of the BISCAL proposal are to unravel biotic interactions within microbial communities for understanding and predicting microbial community assembly and functioning in terrestrial ecosystems.
The first challenge of this project is to move beyond correlations for identifying and characterizing interactions between microbial groups and to assess the role of these biotic interactions as determinants of microbial community composition. The second challenge is to convert this empirical knowledge into fundamental insights and testable predictions, which can ultimately be used to engineer or steer microbial communities for improving soil functions.
Specific objectives :
- Identifying biotic interactions between microbial groups and assessing their role as determinants of community structure
- Determining to which extent abiotic filters and neutral processes shape microbial communities beyond biotic interactions
- Assessing the consequences of microbial community manipulation for soil functions
- Steering the soil microbiome to ultimately promote the agroecosystem services that are supported by microbes
The BISCAL project holds a ground-breaking potential due to its new direction for advancing fundamental knowledge in microbial community assembly from theory to ecological engineering. Thus, inferring biotic interactions within complex microbial communities is not only crucial for laying the basis for microbial community assembly rules but can also potentially pave the way for new approaches allowing us to steer these communities.
Laboratoire : Lipides, Nutrition, Cancer
This program has the objective to explain the molecular mechanisms by which NLRP3 could influence CD8 activation and Th17 differentiation and promotes switch to inflammatory Th17 polarization but also to decipher if NLRP3 expression in T cells controls antitumor immune response.
This study will be the first study to decipher the role of NLRP3 protein in human and mice CD8 and Th17 cells and will make the proof of concept that NLRP3 could be a target to boost antitumor immune response.