Biochimie du Peroxysome, inflammation et métabolisme lipidique

The objective of the laboratory is to deepen our understanding of peroxisome metabolism:
• the functions of the peroxisomal transporters ABCD1, ABCD2 and ABCD3;
• the functions of the peroxisomal enzyme ACOX1;
• peroxisome / mitochondrial relationships;
• peroxisomal metabolism, inflammation, oxidation, and lipid status in oligodendrocytes, neurons, and microglial cells; myelination is addressed in oligodendrocytes;
• the biological activities of very long-chain fatty acids and lipid peroxidation products (in particular oxysterols) on nerve cells (microglial cells) that are deficient or not in ABCD1 or ACOX1.
In collaboration with clinicians, the laboratory is investigating biomarkers of X-ALD, the most common peroxisomal leukodystrophy associated with ABCD1 deficiency. With members of the Neurology team (University Hospital of Dijon), the laboratory is also involved in the identification of lipid biomarkers of Alzheimer’s disease and multiple sclerosis to clarify the relationships between lipid metabolism, demyelination and amyloidogenesis. The laboratory is also evaluating new neuroprotective and myelinating drugs through cell model developments. The molecules concerned are either of natural origin (fatty acids, vitamins, polyphenols and phytosterols) or of synthesis. The laboratory is also interacting with other components within the University of Burgundy in the field of nanosciences (Targeting peroxisome and mitochondria with functionalized nanoparticles)